Tremonti is the lead guitarist and founding member of hard rock/post-grunge bands Creed and Alter Bridge.
On December 14, 2002, Tremonti married Victoria Rodriguez, with whom he has two sons, Austen and Pearson. They currently reside in Orlando, Florida.
In 2008 Tremonti released an instructional guitar documentary DVD titled Mark Tremonti: the Sound & the Story, in which he teaches his guitar solos. He also teaches warm-ups, alternate tunings, finger picking style, legato techniques and other advanced exercises.